At Livingstone Dermatology, we understand that your skin is a reflection of your health and well-being. We are committed to the latest advancements in dermatological science, and dedicated to providing you with quality care.
Healthy and glowing skin starts from within and sometimes, it just needs the right boost. Polynucleotides (PN) and skin boosters are advanced injectable treatments designed to rejuvenate the skin at a cellular level. Rather than simply filling or tightening, these treatments work by improving hydration, elasticity and repair from deep within the skin.
In Singapore, where our climate and lifestyle can stress the skin, PN and skin boosters have become popular for those seeking natural and refreshed results without drastic changes or downtime.
Polynucleotides are biocompatible molecules derived from salmon DNA, known for their powerful regenerative and healing properties. When injected into the skin, they stimulate fibroblast activity. These are the cells responsible for producing collagen, elastin and hyaluronic acid (HA). This process improves skin texture, firmness and resilience over time.
Unlike fillers, which restore lost volume, polynucleotides encourage your skin to repair and renew itself. The result is a gradual, natural-looking improvement in skin quality, achieving a brighter, smoother and more supple appearance.
Skin boosters are microinjections of hyaluronic acid and nourishing ingredients that deeply hydrate the skin. Think of them as a moisture reservoir beneath your skin’s surface that functions to improve plumpness, smoothness and glow.
While topical skincare hydrates only the outermost layer, skin boosters deliver lasting hydration from within, revitalising dull and tired skin, as well as improving fine lines caused by dryness or sun exposure.
| LEVEL OF SEVERITY | WHAT WE USUALLY DO |
|---|---|
| Mild or intermittent eczema |
|
| Moderate or frequent flare-ups |
|
| Severe or resistant eczema |
|
Although both treatments aim to enhance skin quality, they work through different mechanisms. This includes:
| ASPECT | POLYNUCLEOTIDES | SKIN BOOSTERS | |
|---|---|---|---|
| Main function | Stimulates tissue repair and collagen regeneration | Provides deep hydration and improves elasticity | |
| Composition | Fragments of salmon DNA | Hyaluronic acid-based | |
| Results | Firmer and healthier skin over time | Immediate glow and hydration | |
| Longevity | Gradual results that improve over weeks to months | Quicker visible results lasting several months | |
| Best for | Dull, thinning or ageing skin needing rejuvenation | Dehydrated or uneven skin needing radiance | |
Due to their contrasting mechanisms, many patients can benefit from combining both treatments for immediate hydration and a long-lasting glow.
Both treatments are designed to enhance skin health, but they act through different biological mechanisms that complement each other.
Polynucleotides offer cell regeneration from within
Salmon DNA is chosen for their compatibility with human tissues. These fragments are extracted and purified to create a highly potent and effective solution. When injected into the skin, they act as biological “signals” that awaken your skin’s natural repair system.
They work through:
Skin Boosters offer deep hydration and radiance
Meanwhile, skin boosters are primarily made of hyaluronic acid, a natural molecule found in the skin that can hold up to 1,000 times its weight in water.
When injected, hyaluronic acid acts like a moisture reservoir within the dermis, providing long-lasting hydration. It works by:
Together or individually, these treatments offer:
| POLYNUCLEOTIDES | SKIN BOOSTERS |
|---|---|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Both treatments are versatile and minimally invasive, designed to revitalise or rejuvenate ageing skin. They also address a broad range of skin concerns, such as:
While polynucleotides and skin boosters share similar goals, their mechanisms and outcomes differ. This includes:
Choose Polynucleotides
Choose Skin Boosters
Both polynucleotides and skin boosters are gentle, in-clinic injectable treatments designed to enhance your skin’s health from within. Generally, the treatment consists of:
Before the treatment
Our dermatologist will start with a detailed consultation to understand your skin type, goals and any existing conditions. During this visit, you will discuss which treatment best suits your concerns.
The process entails:
During the treatment
The treatment is performed with precision and care, taking around 30 to 60 minutes depending on the areas treated.
After the treatment
You can resume most normal activities immediately after the session, though your skin may appear slightly pink or bumpy at the injection sites for a few hours.
It is completely normal to notice:
Post-treatment care tips
Our dermatologist will provide tailored aftercare advice, but general recommendations include:
Polynucleotides do not change the shape of your face or add volume. Instead, they revitalise your skin at a cellular level, helping it repair and restore its natural balance.
You can expect:
The effects develop progressively over several weeks as collagen and elastin production increase. Most patients describe their skin as looking well-rested and naturally radiant rather than altered or overfilled.
Skin boosters, on the other hand, deliver deep and lasting hydration by replenishing hyaluronic acid within the skin. Results are usually visible within the first week and continue to improve over the next few weeks.
You will notice:
Both treatments complement each other beautifully as polynucleotides strengthen and repair, while skin boosters hydrate and smooth. When combined in a tailored plan, they can help maintain long-term skin health and radiance.
The number of sessions varies depending on your skin condition, goals and age. Our dermatologist will recommend a personalised plan.
But generally, it looks like:
Polynucleotides
Polynucleotides are designed to work biologically, so results build up naturally as your skin regenerates.
Skin Boosters
Many patients enjoy alternating polynucleotide and skin booster treatments for comprehensive rejuvenation, restoring skin structure while maintaining a luminous, hydrated finish.
Healthy and radiant skin does not happen overnight. It is the result of consistent care and the right treatment plan tailored to your skin’s unique needs. Whether you are looking to restore hydration, smooth fine lines or repair tired and dull skin, polynucleotides and skin boosters offer effective, natural-looking rejuvenation with minimal downtime.
During your consultation, our dermatologist will assess your skin condition, discuss your goals and recommend a customised approach. Take the first step towards refreshed, resilient and glowing skin. Book your appointment today and let our experienced dermatologists guide you to a healthier complexion that looks and feels naturally renewed.
Are polynucleotides and skin boosters safe?
Yes. Both treatments are medically proven and widely used for skin rejuvenation. Polynucleotides are derived from purified DNA fragments, while skin boosters contain biocompatible hyaluronic acid. Both are well-tolerated with minimal risk when performed by a trained dermatologist.
Do these treatments hurt?
Discomfort is very minimal. A topical anaesthetic cream is applied before treatment to ensure comfort. Most patients describe the sensation as mild pinpricks or pressure, rather than pain.
Is there downtime after the treatment?
You may experience mild redness, pinpoint marks or swelling for a few hours after the procedure. These effects are temporary and usually resolve within a day. Following our dermatologist’s post-care advice helps ensure smooth healing and the best results.
How can I maintain my results?
Consistent skincare, sun protection and regular maintenance sessions every few months can help prolong the benefits. Our dermatologist will create a follow-up schedule suited to your skin’s needs.
Who should avoid these treatments?
You should postpone treatment if you are pregnant, breastfeeding or have active skin infections or inflammation at the injection site. Our doctor will assess your suitability during the consultation to ensure your safety.
