Conditions We Treat

Skin & Food Allergies

At Livingstone Dermatology, we understand that your skin is a reflection of your health and well-being. We are committed to the latest advancements in dermatological science, and dedicated to providing you with quality care.

What are allergies?

Our immune system functions to protect us from harmful stimuli. For example, when a virus enters the body, the immune system detects specific markers on the virus and recognises them as threats. This triggers a series of immune responses to get rid of the virus. Inflammation usually follows as part of the healing process.

Allergies occur when the immune system mistakenly reacts to harmless substances, leading to symptoms like itching, swelling, and rashes. Common allergens include:

  • Pollen
  • Animal dander
  • Eggs
  • Peanuts
  • Tree nuts
  • Shellfish and seafood
  • Wheat
  • Insect stings
  • Latex
  • Medications such as antibiotics
  • Milk
  • Metals like nickel or cobalt
  • Plants
  • Cleaning products or detergents
Skin and food allergic reactions are common, and can range from a mild itch to life-threatening symptoms. Understanding the connection between what we eat and how our skin reacts plays a huge part in managing our allergies effectively.

Why do we have allergies?

Allergies are a result of the immune system reacting to external or foreign substances that enter the body as a way to protect it. Researchers determined that allergies can also be influenced by other factors such as [3]:

  • Genetic predisposition [4]
  • Epithelial barrier dysfunction
  • Loss of immune tolerance
  • Gut issues
  • Microbiome imbalance
  • Changes in the environment [5]
Skin allergy symptoms.
Allergic reactions can cause hives and itching of the skin.

What are the symptoms of skin and food allergies?

Symptoms of allergic reactions may vary according to the type of allergen or how it enters the body. 

Skin allergies

Skin allergies can be classified to 4 main types:

Type of Allergy Causes/Trigger Symptoms
Contact dermatitis (Eczema)
Allergic reaction occurs when the skin comes into direct contact with an allergen, such as nickel, detergent, fragrances, plants, or latex.
  • Redness
  • Itching
  • Dry, cracked skin
  • Scaly appearance (common in lighter skin)
  • Leathery appearance (common in darker skin)
  • Burning sensation
  • Tenderness
  • Swollen bumps
  • Blisters
Urticaria (Hives)
Allergic reactions causing hives can be from exposure through foods, medications, insect stings or bites, infections, or physical contact with an allergen
  • Welts of different sizes, shapes, or even colour
  • Itching
  • Swelling, around the eyes, lips, or cheeks
Eczema is caused by a weakened or damaged skin barrier, which leads to inflamed and dry skin. Allergic reactions can cause eczema flares.
  • Itching
  • Redness
  • Dry, cracked skin
  • Bumps or blisters
Angioedema
Allergic angioedema causes swelling that can be triggered by contact with an allergen, food allergies, medications, or insect stings or bites. Allergic angioedema can also occur with urticaria
  • Swelling around the face, eyes, mouth
  • Abdominal pain
  • Diarrhoea
  • Nausea and vomiting
  • Swelling of the hands or feet
  • Difficulty breathing

Food allergies

Food allergies are a growing concern, which affects 4 to 8% of children and 5% of adults in the population [6]. As the name suggests, the allergic reaction occurs after ingestion of the allergen. Scientists group different types of food allergies based on the immune reactions involved:

Type of Allergy Causes/Trigger Symptoms
IgE-mediated food allergies
This is the most common type of food allergies, the immune system reacts to the allergen by increasing levels of immunoglobulin E (IgE) antibodies, leading to allergy symptoms [6, 7]
  • Itching
  • Hives
  • Swelling (angioedema)
  • Abdominal pain
  • Tightening of the bronchi, which may lead to difficulty breathing
  • Low blood pressure
  • Shock
Non-IgE-mediated food allergies

In non-IgE-mediated food allergies, other cells of the immune system react to the allergen without involving Ig-E antibody release. Common non-IgE-mediated food allergic disorders include: 

  • Food protein-induced enterocolitis syndrome (FPIES)
  • Food protein-induced allergic proctocolitis (FPIAP)
  • Food protein-induced enteropathy (FPE) 
  • Celiac disease
  • Food-associated atopic dermatitis 
 

Lung disorders such as Heiner syndrome (cow’s milk hypersensitivity) [7,

  • Vomiting
  • Diarrhoea
  • Bloating
  • Blood or mucous in stool
  • Rashes
  • Lethargy
  • Pallor
  • Oedema
  • Shock
Mixed IgE and non-IgE-mediated food allergies
Common disorders associated are atopic dermatitis, eosinophilic oesophagitis
  • Rashes
  • Hives
  • Swelling
  • Vomiting
  • Diarrhoea
  • Lethargy
  • Pallor

Food Allergy vs Food Intolerance

Food allergies and food intolerances are commonly mistaken for each other. However, both are different in many ways. Here are the key differences:

Food allergies Food intolerances
Systems involved
Immune system
Gastrointestinal system
Causes
Extreme immune response to allergens in food
Inability of the gastrointestinal system to digest or process the food, such as in lactose intolerance
Symptom onset
Reaction can be immediate or within minutes
Symptoms may appear later, up to several hours
Occurrence
Reaction happens every time the allergen is encountered
Reaction may depend on the dose of the food, small amounts may not cause a reaction at all
Severity
Can cause life-threatening symptoms, such as anaphylaxis
Not likely to cause life-threatening symptoms, but can make you feel unwell
Diagnosis
Can be diagnosed in a clinic with tests such as skin prick test or patch test
More challenging to diagnose, no specific test available

How are allergies diagnosed?

Diagnosing an allergy can be beneficial in avoiding or minimising occurrences of allergic reactions.

Before conducting the tests, your doctor will ask you about your symptoms, medical history, family history, and your home and work environment
to identify possible allergens you encounter that elicit a reaction.

To identify specific allergens, doctors can perform the following tests:

Skin prick test singapore.
Skin prick tests involve applying a small amount of allergen to the skin and pricking it to check for allergic reactions, with a raised bump indicating sensitivity.
  • Skin prick test – A skin prick test involves the doctor applying a drop of allergen solution on the skin,
    followed by pricking the skin through the solution to allow the body to react.
    Results are evaluated after 15 minutes. This test is relatively simple and quick,
    but may lead to false negatives if the patient is on antihistamines at the time of the test.
  • Patch test – A patch test involves the doctor attaching patches of chemicals or allergens to the patient’s skin,
    usually on the back. The allergic reaction is typically observed after 48 to 72 hours.
    Patch tests are important for diagnosis of contact dermatitis.
  • Food challenges – Food challenges are conducted to test for food allergies.
    Doctors can perform either an oral food challenge or a food challenge following an elimination diet.
    Oral food challenges are relatively simpler compared to the latter as they can be performed in the doctor’s office.
    Elimination diets require a period of about 6 weeks before the foods are reintroduced in the food challenge.
  • Blood tests – Blood tests are used to measure IgE levels in response to an allergen.

Treatment for allergies

Naturally, the best way to manage allergies and allergic reactions is to avoid or minimise contact with allergens. However, sometimes it may not be entirely possible or feasible.

Skin allergies can be treated with topical creams and ointments, as well as oral medications:

  • Topical ointments or creams – Topical application of hydrocortisone, calamine or other soothing ingredients such as camphor can help relieve itching and inflammation of the skin.
  • Antihistamines – Medications such as diphenhydramine and cetirizine
    can relieve itchiness and hives, aside from common allergic rhinitis symptoms.
  • Corticosteroids – Corticosteroids such as desonide can relieve inflammation and itching from allergic reactions. However, corticosteroids should not be used for long periods of time due to risk of skin atrophy.
  • Immunosuppressants – Skin allergies related to eczema can be treated with immunosuppressive drugs. However, this is only reserved for severe cases.
  • Epinephrine injection – Severe allergic reactions that lead to anaphylaxis can be life-threatening and should be treated with an epinephrine injection.

Food allergies can be treated with:

  • Antihistamines – The use of antihistamines is recommended for acute and non-life-threatening allergic reactions [11].
  • Corticosteroids – Corticosteroids can also be used to relieve swelling in an allergic reaction to foods.
  • Epinephrine injection – Carrying an epinephrine injection, commonly known as an EpiPen, is important for people with severe allergies. Accidental ingestion of allergens may be unexpected, so it is important to always be prepared.
  • Anti-IgE – Monoclonal antibody omalizumab neutralises excess IgE in the body, which can reduce inflammatory response to allergens [11].

How to prevent or avoid allergic reactions

Allergies can be difficult to treat, and the symptoms may interfere with the ability to perform daily tasks. Hence, prevention may be more beneficial in the long run. Several steps you can take to reduce the risk of having an allergic reaction include:

  • Identify your allergens and be mindful – Avoiding allergens can be done by being aware of your allergies and avoiding them in food ingredients, household products, or skin care products. An allergy test can also help identify potential allergens you may not have encountered before.
  • Not sharing items – Personal items such as utensils, clothing, or towels should not be shared to limit cross-contamination and possible exposure to allergens.
  • Maintaining hygiene – For example, frequent hand washing can limit exposure to allergens.
  • Carry medications – Bring allergy medications such as antihistamine pills or, in severe cases, epinephrine injections everywhere you go. Medications can mitigate symptoms, as well as avoid life-threatening reactions. Always have these medications available in your home.
  • Limit stress – Although stress does not cause allergies, it can exacerbate conditions associated with allergies, such as atopic dermatitis.

Limiting allergen exposure can be effective in reducing the chances of allergic reactions, but it is always important to have treatment available anytime. This is especially crucial for those who have severe reactions to allergens.

If you are still concerned and doubtful about what you might be allergic to, reach out to us for a comprehensive allergy diagnosis and consultation. Our dermatologists will address your concerns and questions about skin and food allergies.

Frequently Asked Questions

When should I see a doctor for a skin and food allergy?

If you have frequent allergic symptoms, or have had a serious allergic reaction in the past, visiting a doctor is recommended to properly diagnose the allergy. Depending on the type of allergen, up to 81% of people with an allergy may be polysensitised to other allergens as well [12]. Getting an allergy test can identify other potential allergens, hence minimising the risk of triggering a reaction.

Sometimes allergies can go away or change as we get older, this may be due to changes in our environment and desensitization to allergens.

Yes, it is possible that you can build tolerance against certain allergens. However, this is unlikely for severe allergic reactions to foods. Desensitization therapy, called allergen immunotherapy (AIT) is conducted by introducing the allergen in incremental doses. However, the current indication is only available for pollen allergies.

Severe allergic reactions can be life-threatening when it causes you to have difficulty breathing, extensive swelling, a drop in blood pressure, and loss of consciousness.

Yes, allergies can develop later in life, this can be due to several factors such as changes in the environment or changes in the immune system. You may also encounter new allergens later in life.

References

  1. Primorac D, Vrdoljak K, Brlek P, Pavelić E, Molnar V, Matišić V, Erceg Ivkošić I, Parčina M. Adaptive Immune Responses and Immunity to SARS-CoV-2. Front Immunol. 2022 May 4;13:848582. doi: 10.3389/fimmu.2022.848582. PMID: 35603211; PMCID: PMC9114812.
  2. Chen L, Deng H, Cui H, Fang J, Zuo Z, Deng J, Li Y, Wang X, Zhao L. Inflammatory responses and inflammation-associated diseases in organs. Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. PMID: 29467962; PMCID: PMC5805548.
  3. Krempski JW, Dant C, Nadeau KC. The origins of allergy from a systems approach. Ann Allergy Asthma Immunol. 2020 Nov;125(5):507-516. doi: 10.1016/j.anai.2020.07.013. Epub 2020 Jul 21. PMID: 32702411.
  4. Carter CA, Frischmeyer-Guerrerio PA. The Genetics of Food Allergy. Curr Allergy Asthma Rep. 2018 Jan 26;18(1):2. doi: 10.1007/s11882-018-0756-z. PMID: 29374367.
  5. Cecchi L, D’Amato G, Annesi-Maesano I. External exposome and allergic respiratory and skin diseases. J Allergy Clin Immunol. 2018 Mar;141(3):846-857. doi: 10.1016/j.jaci.2018.01.016. PMID: 29519451.
  6. Pelz BJ, Bryce PJ. Pathophysiology of Food Allergy. Pediatr Clin North Am. 2015 Dec;62(6):1363-75. doi: 10.1016/j.pcl.2015.07.004. Epub 2015 Sep 5. PMID: 26456437.
  7. Yu W, Freeland DMH, Nadeau KC. Food allergy: immune mechanisms, diagnosis and immunotherapy. Nat Rev Immunol. 2016 Dec;16(12):751-765. doi: 10.1038/nri.2016.111. Epub 2016 Oct 31. PMID: 27795547; PMCID: PMC5123910.
  8. Nowak-Węgrzyn A, Katz Y, Mehr SS, Koletzko S. Non-IgE-mediated gastrointestinal food allergy. J Allergy Clin Immunol. 2015 May;135(5):1114-24. doi: 10.1016/j.jaci.2015.03.025. PMID: 25956013.
  9. Rusznak C, Davies RJ. ABC of allergies. Diagnosing allergy. BMJ. 1998 Feb 28;316(7132):686-9. doi: 10.1136/bmj.316.7132.686. Erratum in: BMJ 1998 Apr 4;316(7137):1078. PMID: 9522798; PMCID: PMC1112683.
  10. Chinthrajah RS, Tupa D, Prince BT, Block WM, Rosa JS, Singh AM, Nadeau K. Diagnosis of Food Allergy. Pediatr Clin North Am. 2015 Dec;62(6):1393-408. doi: 10.1016/j.pcl.2015.07.009. Epub 2015 Sep 7. PMID: 26456439; PMCID: PMC5316471.
  11. Muraro A, Werfel T, Hoffmann-Sommergruber K, Roberts G, Beyer K, Bindslev-Jensen C, Cardona V, Dubois A, duToit G, Eigenmann P, Fernandez Rivas M, Halken S, Hickstein L, Høst A, Knol E, Lack G, Marchisotto MJ, Niggemann B, Nwaru BI, Papadopoulos NG, Poulsen LK, Santos AF, Skypala I, Schoepfer A, Van Ree R, Venter C, Worm M, Vlieg-Boerstra B, Panesar S, de Silva D, Soares-Weiser K, Sheikh A, Ballmer-Weber BK, Nilsson C, de Jong NW, Akdis CA; EAACI Food Allergy and Anaphylaxis Guidelines Group. EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Allergy. 2014 Aug;69(8):1008-25. doi: 10.1111/all.12429. Epub 2014 Jun 9. PMID: 24909706.
  12. Cacheiro-Llaguno C, Mösges R, Calzada D, González-de la Fuente S, Quintero E, Carnés J. Polysensitisation is associated with more severe symptoms: The reality of patients with allergy. Clin Exp Allergy. 2024 Aug;54(8):607-620. doi: 10.1111/cea.14486. Epub 2024 Apr 27. PMID: 38676405.

Your Journey to Healthy Skin Starts Here

Whether you’re dealing with a specific skin concern or seeking to enhance your natural beauty, Livingstone Dermatology is here to guide you on your journey to healthy, radiant skin. 

Schedule an appointment today and experience the Livingstone standard of care in a welcoming, professional environment.